Purpose. To evaluate the safety and efficacy of intracameral vancomycin during cataract surgery using a standardized dosage\nand delivery technique. Methods.The charts of 20,719 consecutive eyes that underwent phacoemulsification with intraocular lens\nimplantation in a single ambulatory surgery center were retrospectively reviewed over a 5-year period. Results. The first 11,333\nconsecutive cases did not receive intracameral vancomycin, whereas the next 9,386 consecutive cases all received intracameral\nvancomycin. There were no significant differences in the baseline characteristics between the cohort of subjects who received\nintracameral vancomycin and the cohort of subjects that did not. There were a total of 11 subjects (0.97 cases per 1,000) that\ndeveloped postoperative endophthalmitis in the group that did not receive intracameral vancomycin, whereas there were no cases\nof postoperative endophthalmitis in the group that received intracameral vancomycin (p = 0.0015).The overall rate of intraoperative\nand postoperative complications and the final postoperative visual acuities were similar among cohorts. There were no cases of toxic\nanterior segment syndrome occurring in either group during the study period. Conclusions. Routine administration of intracameral\nvancomycin during cataract surgery significantly decreased the incidence of postoperative endophthalmitis and was not associated\nwith an increased incidence of postoperative adverse events.
Loading....